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p63 expression in odontogenic cysts.

L Lo Muzio1, A Santarelli, R Caltabiano

  • 1Department of Surgical Sciences, University of Foggia, Foggia, Italy. lomuziol@tin.it

International Journal of Oral and Maxillofacial Surgery
|August 2, 2005
PubMed
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p63 protein expression in odontogenic cysts can help identify aggressive types. Keratocysts show the most intense p63 labeling, suggesting a proliferative compartment.

Area of Science:

  • Oral pathology
  • Immunohistochemistry
  • Molecular biology

Background:

  • Odontogenic cysts are common jaw lesions.
  • Differentiating cyst types is crucial for treatment.
  • p63 is a protein marker of epithelial proliferation.

Purpose of the Study:

  • To investigate p63 expression in different odontogenic cysts.
  • To correlate p63 expression with cyst behavior.
  • To assess p63 as a diagnostic marker.

Main Methods:

  • Immunohistochemical analysis of p63 expression.
  • Study included 123 odontogenic cysts: 30 follicular (FC), 35 radicular (RC), 53 keratocysts (OKCs), 1 glandular, and 4 calcifying.
  • Quantification of p63-positive cells in cyst epithelium.

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Main Results:

  • Radicular cysts (RCs) showed p63 positivity in basal, parabasal, and intermediate layers.
  • Follicular cysts (FCs) exhibited p63 positivity mainly in basal and parabasal layers.
  • Odontoid keratocysts (OKCs) displayed the most intense and diffuse p63 labeling.

Conclusions:

  • p63 expression patterns vary significantly among odontogenic cyst types.
  • Intense p63 labeling in OKCs suggests a suprabasal proliferative compartment.
  • p63 may serve as a marker for identifying cysts with a more aggressive phenotype.