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Is low-risk hypertension fact or fiction? cardiovascular risk profile in the TROPHY study

Shawna D Nesbitt1, Stevo Julius, David Leonard

  • 1Department of Internal Medicine, Division of Hypertension, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8899, USA. shawna.nesbitt@utsouthwestern.edu

American Journal of Hypertension
|August 2, 2005
PubMed

Insights

High normal blood pressure often coexists with other cardiovascular risks. Early intervention may be crucial for preventing hypertension and reducing disease risk.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Preventive Medicine

Background:

  • The Trial of Preventing Hypertension (TROPHY) Study investigates treating high normal blood pressure.
  • Baseline data on cardiovascular risk factors were collected from 809 randomized subjects.
  • Identified risk factors include elevated cholesterol, BMI, insulin, and heart rate.

Purpose of the Study:

  • To determine if candesartan cilexetil reduces progression to hypertension compared to placebo.
  • To analyze the cardiovascular risk factor profile of individuals with high normal blood pressure.

Main Methods:

  • A 4-year randomized, placebo-controlled, multicenter clinical trial.
  • Involves 809 subjects diagnosed with high normal blood pressure.
  • Treatment with a low-dose angiotensin receptor blocker (candesartan cilexetil) or placebo.

Main Results:

  • Participants (mean age 49) with high normal BP (mean 134/85 mm Hg) exhibited numerous cardiovascular risk factors.
  • 96% had at least one additional risk factor.
  • 81% had two or more, and 13% had five or more risk factors.

Conclusions:

  • Cardiovascular disease risk increases even before hypertension is diagnosed.
  • Overall risk in high normal BP individuals is a combination of rising BP and other factors.
  • Isolated low-risk hypertension is uncommon in this population.
Abstract

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