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Related Experiment Videos

LXRs regulate the balance between fat storage and oxidation.

Nada Y Kalaany1, Karine C Gauthier, Ann Marie Zavacki

  • 1Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

Cell Metabolism
|August 2, 2005
PubMed
Summary

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Liver X receptors (LXRs) govern how the body balances storing and burning dietary fat. LXR-deficient mice resist obesity by increasing energy expenditure, not by altering fat synthesis.

Area of Science:

  • Metabolic pathways
  • Lipid and cholesterol regulation
  • Obesity research

Background:

  • Liver X receptors (LXRs) are known regulators of cholesterol homeostasis.
  • The role of LXRs in overall lipid homeostasis and obesity is not fully understood.

Purpose of the Study:

  • To investigate the role of LXRs in hepatic lipid metabolism and obesity resistance.
  • To elucidate the mechanisms underlying LXR-dependent regulation of energy balance.

Main Methods:

  • Utilized LXR null mice and diet-induced obesity models.
  • Analyzed hepatic lipid metabolism, thyroid hormone production, and energy expenditure.
  • Examined gene expression related to lipogenesis and oxidative phosphorylation.

Main Results:

Related Experiment Videos

  • LXR null mice exhibited defective hepatic lipid metabolism and resistance to diet-induced obesity.
  • This obesity resistance was cholesterol-dependent and linked to aberrant thyroid hormone production.
  • Obesity resistance was attributed to increased energy dissipation via uncoupled oxidative phosphorylation in muscle and adipose tissue, not altered lipogenesis.

Conclusions:

  • LXRs play a critical role in managing dietary lipid metabolism and energy balance.
  • LXRs selectively sense dietary cholesterol to control the partitioning between fat storage and oxidation.
  • These findings reveal a novel mechanism linking cholesterol sensing to energy expenditure and obesity prevention.