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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
[Epidemiology of respiratory syncytial virus infections in the Canary Islands]
A Bosch Ferrer1, B Palop Borrás, B Lafarga Capuz
1Unidad Microbiología, Hospital Ntra. Sra. del Pino, Las Palmas de Gran Canaria.
Insights
Respiratory syncytial virus (RSV) causes severe respiratory infections in young children, with yearly winter outbreaks mirroring patterns seen in temperate climates. Our study identified RSV in 35.8% of hospitalized children, primarily infants aged 1-6 months.
Area of Science:
- Pediatrics
- Virology
- Epidemiology
Context:
- Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants and young children.
- RSV outbreaks typically occur annually during winter or spring in temperate regions.
- Understanding local epidemiological patterns is crucial for public health interventions.
Purpose:
- To investigate the prevalence and epidemiological characteristics of respiratory syncytial virus (RSV) infections in hospitalized children under three years of age.
- To compare the observed RSV infection patterns with those documented in temperate climates.
Summary:
- A study of 634 hospitalized children (under 3 years) revealed that 227 (35.8%) had RSV infections.
- RSV cases exhibited a distinct yearly epidemic pattern, with 86.8% occurring during winter months.
- The majority of RSV infections (67.4%) were in infants aged 1-6 months, with a 1.2:1 male to female ratio. An antibody response was detected in 26.9% of cases.
Impact:
- The findings confirm that RSV infections in this island population follow similar epidemiological trends as observed in temperate climates.
- This data can inform targeted prevention and management strategies for RSV in young children within the studied region.
Abstract:
Respiratory syncytial virus (RSV) is the major cause of lower respiratory tract infection in young children. Outbreaks of RSV infection occur yearly during the winter or spring in temperate climates. Our study of 634 hospitalized children under 3 years of age with bronchiolitis and pneumonia (November 1988 to January 1990) revealed that 227 (35.8%) had VRS infections. These cases showed a yearly epidemic pattern with 86.8% of the cases occurring during the winter. Furthermore, 67.4% of the cases occurred in children between 1-6 months of age and the boy/girl ration was 1.2/1. In 26.9% of the infections there was an antibody response. These results for RSV infection on this island show the same epidemiological pattern as that in the temperate climates.
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