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Gastrin and cancer: a review
Audrey Ferrand1, Timothy C Wang
1IFR31, Institut Louis Bugnard, BP 84225, Unité INSERM 531, Biologie et Pathologie Digestives, 31432 TOULOUSE, Cedex 4, France. audrey.ferrand@toulouse.inserm.fr
Cancer Letters
|August 2, 2005
Summary
Gastrin, a hormone regulating stomach acid, is now recognized for its role in cancer. Recent research highlights progastrin and glycine-extended gastrin
Area of Science:
- Endocrinology
- Oncology
- Molecular Biology
Background:
- John Sydney Edkins first identified gastrin in 1905 for its role in gastric acid secretion.
- While gastrin's function in acid secretion is established, its isoforms are increasingly linked to cancer development.
- Recent discoveries include the biological activity of progastrin and glycine-extended gastrin.
Purpose of the Study:
- To provide an overview of the roles of gastrin peptides in cancer.
- To highlight recent advances in understanding progastrin and its derivatives in oncogenesis.
Main Methods:
- Review of molecular and cellular studies.
- Analysis of integrated studies using animal models.
- Investigation of progastrin-derived peptides and their receptors.
Main Results:
- Progastrin and glycine-extended gastrin exhibit biological activity relevant to cancer.
- Animal models demonstrate the role of progastrin-derived peptides in cancer progression.
- Receptor interactions for these peptides are crucial in cancer pathways.
Conclusions:
- Gastrin peptides, including progastrin and its variants, play significant roles in cancer.
- Further research into these peptides and their receptors can inform cancer therapies.