Related Experiment Video
Updated: Jul 23, 2026

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers
Published on: December 1, 2017
Cell mediated and antibody immune response to inactivated hepatitis A vaccine
P Schmidtke1, P Habermehl, M Knuf
1Pediatric Immunology and Infectious Diseases, Children's Hospital, University of Mainz, Obere Zahlbacher Str.63, DMG, 55131 Mainz, Germany. peter.schmidtke@uni-mainz.de
Abstract:
The humoral and cellular immune response to inactivated hepatitis A vaccine was investigated dynamically in a time elapse study over 1 year. Fourty-five healthy volunteers, seronegative for anti-HAV, were vaccinated with 1440 enzyme-linked immunosorbent assay units (EU) of formalin-inactivated hepatitis A virus following a 0--6-month schedule. Serum anti-HAV levels and HAV-specific proliferation of peripheral blood mononuclear cells were measured at several time points over a 26- and 28-week period after the first and second injection, respectively. Distinct B and T cell responses were determined within 14 days after primary vaccination. The booster vaccination-induced immediate peak levels for the humoral (anti-HAV GMC=5376mIU/ml) as well as the cellular (median Deltacpm=14173cpm) response.
Related Concept Videos
Humoral Immune Responses
Vaccinations
Active versus Passive Immunity
Active Immunity
Active immunity refers to the resistance one develops...
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Vaccines
Hepatitis

