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B cell development and receptor diversity during aging.

David Allman1, Juli P Miller

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6082, USA. dallman@mail.med.upenn.edu

Current Opinion in Immunology
|August 2, 2005
PubMed
Summary
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Aging impairs early B cell development, altering the mature B cell repertoire and function. This study proposes a model for age-related changes in B cell immunity.

Area of Science:

  • Immunology
  • Aging research
  • Hematopoiesis

Background:

  • B cell production (genesis) decreases with age.
  • The mechanisms behind age-related B cell decline are poorly understood.
  • The impact on peripheral B cell function remains unclear.

Purpose of the Study:

  • To investigate the effects of aging on B cell development.
  • To understand how aging impacts the peripheral B cell repertoire.
  • To propose a model for age-related changes in B cell function.

Main Methods:

  • Review of recent studies on aging and B cell development.
  • Analysis of B cell genesis in bone marrow.
  • Assessment of the peripheral B cell repertoire.

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Main Results:

  • Aging affects very early B cell progenitors.
  • This leads to alterations in the peripheral B cell repertoire.
  • Consequently, mature B cell function is modified.

Conclusions:

  • A model is proposed where aging progenitors drive changes in B cell populations.
  • Age-related shifts in the B cell repertoire impact immune responses.
  • Further research is needed to fully elucidate these age-related immune changes.