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Association of fibrinogen and C-reactive protein with severity of preeclampsia
Yusuf Ustün1, Yaprak Engin-Ustün, Mansur Kamaci
1Yüzüncü Yil University, Faculty of Medicine, Gynecology and Obstetrics Department, Van, Turkey. ustunyus@yahoo.com
Insights
Preeclampsia is associated with elevated levels of plasma fibrinogen and C-reactive protein (CRP). These markers show a good correlation with mean arterial pressure, indicating disease severity.
Area of Science:
- Obstetrics and Gynecology
- Cardiovascular Research
- Biomarkers in Pregnancy
Background:
- Preeclampsia is a serious pregnancy complication characterized by high blood pressure.
- Plasma fibrinogen and C-reactive protein (CRP) are inflammatory markers potentially involved in preeclampsia pathogenesis.
Purpose of the Study:
- To quantify plasma fibrinogen and CRP levels in preeclampsia.
- To investigate the association between these markers and preeclampsia severity.
Main Methods:
- Compared fibrinogen and CRP levels in normal pregnancy, mild preeclampsia, and severe preeclampsia groups.
- Utilized mean arterial pressure (MAP) as a severity indicator.
- Employed Kruskal-Wallis and Spearman's rank correlation tests for statistical analysis.
Main Results:
- Significantly higher plasma CRP and fibrinogen levels were observed in preeclampsia patients compared to normal pregnancies.
- Strong correlations were found between MAP and both CRP (r=0.515) and fibrinogen (r=0.383) in preeclampsia.
Conclusions:
- Elevated plasma fibrinogen and CRP are characteristic of preeclampsia.
- CRP demonstrates a significant correlation with disease severity, as indicated by MAP.
Objective:
The aim of this study was to determine the levels of plasma fibrinogen and C-reactive protein (CRP) in preeclampsia and their association with the severity of the disease.
Study Design:
CRP and plasma levels of fibrinogen were investigated in 26 cases of normal pregnant women, 26 cases with mild preeclampsia and 26 cases with severe preeclampsia in the third trimester of pregnancy. Mean arterial pressure (MAP) was used as an indicator of the severity of the disease. Analysis of variance with the Kruskal-Wallis test was used when three groups were compared. For correlations, Spearman's rank correlation tests were used. A receiver operating characteristic curve was constructed to evaluate the sensitivity and specificity of CRP.
Results:
Plasma CRP and fibrinogen levels in mild and severe preeclampsia patients were markedly higher than that of normal third trimester pregnant women. There were significant correlations between MAP and CRP (r = 0.515, p = 0.0001) and MAP and fibrinogen parameters (r = 0.383, p = 0.005) in pregnancies complicated with preeclampsia.
Conclusion:
We found higher levels of fibrinogen and CRP and presence of good correlation between CRP and MAP in preeclampsia.
