Related Experiment Video

Updated: Aug 4, 2026

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers
06:34

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

Reactogenicity and immunogenicity profile of a two-dose combined hepatitis A and B vaccine in 1-11-year-old children

D Roberton1, H Marshall, T M Nolan

  • 1Department of Paediatrics, Children, Youth and Women's Health Service, North Adelaide SA 5006, Australia. don.roberton@adelaide.edu.au

Vaccine
|August 2, 2005
PubMed

Insights

A new two-dose hepatitis A and B vaccine shows comparable safety and immunogenicity to the existing three-dose schedule in children. This simplified vaccination offers excellent protection against both viruses.

Area of Science:

  • Pediatric Vaccinology
  • Infectious Disease Prevention
  • Immunology

Background:

  • The established hepatitis A and B vaccine requires a three-dose schedule (0, 1, 6 months).
  • Evaluating alternative, potentially more convenient vaccination schedules is crucial for public health.
  • Combined vaccines offer advantages in simplifying immunization protocols.

Purpose of the Study:

  • To compare the safety, reactogenicity, and immunogenicity of a two-dose combined hepatitis A and B vaccine with a three-dose regimen.
  • To assess vaccine performance across different pediatric age groups (1-5 and 6-11 years).

Main Methods:

  • A study involving 511 children aged 1-11 years who were unvaccinated against hepatitis A or B.
  • Administration of either a two-dose (0, 6 months) or a three-dose (0, 1, 6 months) combined hepatitis A and B vaccine.
  • Evaluation of reactogenicity, safety, and immunogenicity (seroprotection for HepB, seroconversion for HepA) one month post-vaccination.

Main Results:

  • Both vaccine schedules were well-tolerated, safe, and immunogenic in children.
  • The two-dose schedule demonstrated a reactogenicity profile comparable to the three-dose schedule.
  • Both regimens achieved high efficacy: ≥98% seroprotection against hepatitis B and 100% seroconversion against hepatitis A.

Conclusions:

  • A two-dose combined hepatitis A and B vaccine is a safe and effective alternative to the established three-dose schedule.
  • The simplified two-dose regimen provides robust immunogenicity and protection in children.
  • This offers a more convenient vaccination option for hepatitis A and B prevention.

More Related Videos

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency09:04

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency

Published on: May 11, 2020

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique09:37

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Published on: September 23, 2022

Related Concept Videos

Cross-reactivity00:42

Cross-reactivity

Overview
Vaccinations01:51

Vaccinations

Overview
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...