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Updated: Jul 31, 2026

Controlled Microfluidic Environment for Dynamic Investigation of Red Blood Cell Aggregation
Published on: June 4, 2015
Thermal fluctuations of red blood cell membrane via a constant-area particle-dynamics model
Gianluca Marcelli1, Kim H Parker, C Peter Winlove
1Department of Bioengineering, Imperial College London, London, United Kingdom. g.marcelli@imperial.ac.uk
Abstract:
We describe a model of the mechanical properties of the cell plasma membrane using a finite-temperature particle-dynamics simulation of the whole cell, in which a two-dimensional network of virtual particles embedded in a three-dimensional closed surface represents the membrane. The particles interact via harmonic potential and dihedral angle potential and are subject to a constant area constraint. The evolution of the positions of the particles yields the equilibrium state of the membrane and allows determination of the membrane thermal fluctuations and the elastic moduli. We show that time-averaging of the cell-model configurations allows quantitative comparison with experimental data on membrane fluctuations and elastic moduli of the red blood cell.
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