Related Experiment Video
Updated: Aug 16, 2026
Cerebellar Regional Dissection for Molecular Analysis
Published on: December 5, 2020
MRI analysis of cerebellar vermal abnormalities in bipolar disorder
Neil P Mills1, Melissa P Delbello, Caleb M Adler
1Center for Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0559, USA. neil.mills@psychiatry.uc.edu
Objective:
The authors sought to expand previous findings of vermal abnormalities in bipolar disorder patients.
Method:
Magnetic resonance imaging (MRI) morphometry was used to quantify vermal subregion volumes in 18 subjects with first-episode bipolar disorder, 21 subjects with multiple-episode bipolar disorder, and 32 healthy subjects.
Results:
Vermal subregion V2 volume was significantly smaller in multiple-episode bipolar disorder subjects than in first-episode patients and healthy subjects. Vermal subregion V3 was significantly smaller in multiple-episode bipolar disorder subjects than in healthy subjects.
Conclusions:
These results suggest that posterior-inferior cerebellar vermal abnormalities are present in patients with multiple-episode bipolar disorder.
