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Impact of obstructive sleep apnoea on left ventricular mass and global function
D Dursunoglu1, N Dursunoglu, H Evrengül
1Dept of Cardiology, University Medical Faculty, Denizli, Turkey. dursundursunoglu@yahoo.com
The European Respiratory Journal
|August 2, 2005
Summary
Obstructive sleep apnoea syndrome (OSAS) is linked to increased heart muscle mass and impaired heart function. Severe OSAS patients showed significantly higher left ventricular mass and index, indicating potential cardiac dysfunction.
Area of Science:
- Cardiology
- Sleep Medicine
- Pulmonology
Background:
- Obstructive sleep apnoea syndrome (OSAS) is increasingly recognized as a potential contributor to cardiovascular disease.
- Left ventricular hypertrophy and diastolic dysfunction are common in cardiovascular conditions.
Purpose of the Study:
- To evaluate left ventricular mass and myocardial performance index (MPI) in patients diagnosed with OSAS.
- To determine if OSAS severity correlates with cardiac structural and functional changes.
Main Methods:
- 67 patients referred for OSAS evaluation underwent polysomnography and echocardiography.
- Patients were stratified into mild, moderate, and severe OSAS groups based on apnea-hypopnea index (AHI).
- Left ventricular mass (LVM), LVM index (LVMI), and left ventricular MPI were assessed.
Main Results:
- Severe OSAS patients exhibited significantly higher interventricular septum (IVS) and left ventricular posterior wall (LVPW) thickness, LVM, and LVMI compared to mild and moderate OSAS groups.
- Left ventricular MPI was significantly elevated in severe OSAS compared to mild OSAS, suggesting global left ventricular dysfunction.
- Higher blood pressure was noted in the severe OSAS group.
Conclusions:
- Moderate to severe OSAS is associated with increased left ventricular mass and index.
- Patients with severe OSAS demonstrate signs of global left ventricular dysfunction.
- OSAS may play a role in the development of heart failure.