Related Experiment Videos
Effect of cyclodextrin on the pharmacology of antifungal oral azoles
J S Hostetler1, L H Hanson, D A Stevens
1Department of Medicine, Santa Clara Valley Medical Center, San Jose, California.
Antimicrobial Agents and Chemotherapy
|February 1, 1992
Abstract:
Concentrations of oral azoles in serum were compared in a single-dose pharmacologic study in mice. When hydroxypropyl-beta-cyclodextrin was used as a carrier and compared with a standard carrier, polyethylene glycol, drug concentrations determined by bioassay showed that the peak concentration and area under the concentration-time curve were greatly enhanced for itraconazole and saperconazole; moderately enhanced for ketoconazole; but negligibly affected for fluconazole, miconazole, and SCH 42427.