Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Breath acetaldehyde following ethanol consumption.

M K Wong1, B K Scott, C M Peterson

  • 1Sansum Medical Research Foundation, Santa Barbara, CA 93105.

Alcohol (Fayetteville, N.Y.)
|May 1, 1992
PubMed
Summary

Drinking ethanol significantly increases breath acetaldehyde levels, which rapidly partition into breath. Baseline breath acetaldehyde may predict individual differences in ethanol metabolism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation of administrative health data for the identification of endometriosis diagnosis.

Human reproduction (Oxford, England)·2024
Same author

Effect of bimatoprost sustained-release intracameral implant on intraocular pressure and medication burden in patients with prior glaucoma surgery.

Journal francais d'ophtalmologie·2023
Same author

Concomitant Ulnar Styloid Fractures in Distal Radius Osteosynthesis Does Not Impact Radiographic Outcomes, Ulnar Sided Symptoms and Patient Outcomes.

Malaysian orthopaedic journal·2023
Same author

First-in-class Microbial Ecosystem Therapeutic 4 (MET4) in combination with immune checkpoint inhibitors in patients with advanced solid tumors (MET4-IO trial).

Annals of oncology : official journal of the European Society for Medical Oncology·2023
Same author

Subtle choroidal metastasis from breast cancer denied by the patient.

Journal francais d'ophtalmologie·2022
Same author

OCT angiography of papillary squamous cell carcinoma in situ.

Journal francais d'ophtalmologie·2022

Area of Science:

  • Biochemistry
  • Pharmacokinetics
  • Analytical Chemistry

Background:

  • Ethanol metabolism produces acetaldehyde, a toxic compound.
  • Understanding acetaldehyde kinetics is crucial for assessing ethanol's effects.
  • Individual variations in ethanol metabolism are not fully understood.

Purpose of the Study:

  • To investigate the impact of ethanol consumption on breath acetaldehyde levels.
  • To determine the elimination kinetics of ethanol and acetaldehyde in breath.
  • To explore the correlation between baseline and post-ethanol breath acetaldehyde.

Main Methods:

  • Volunteers consumed ethanol (0.3 g/kg) or a placebo.
  • Breath samples were collected pre- and post-ingestion for up to 23.5 hours.
  • Acetaldehyde was quantified using high-performance liquid chromatography; ethanol was measured via breathalyzer.

Main Results:

  • Breath acetaldehyde increased 50-fold post-ethanol, returning to baseline within 3-4 hours.
  • Mean peak blood ethanol reached 0.055% with a half-life of 1.6 hours.
  • Acetaldehyde elimination half-life was 2.25 hours; both showed zero-order elimination initially.
  • A significant correlation (r=0.74) was observed between baseline and peak acetaldehyde levels.

Conclusions:

  • Ethanol intake leads to rapid partitioning of acetaldehyde into breath.
  • Breath acetaldehyde measurement may help identify individual differences in ethanol metabolism.
  • Baseline breath acetaldehyde levels are predictive of post-challenge levels.

Related Experiment Videos