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Effects of ethanol injection to the preoptic area on sleep and temperature in rats
S R Ticho1, M Stojanovic, G Lekovic
1Department of Pharmacology, College of Medicine University of Illinois, Chicago 60612.
Alcohol (Fayetteville, N.Y.)
|May 1, 1992
Abstract:
Bilateral microinjection of ethanol to the preoptic area of rats causes a dose-dependent hypnotic effect at doses that do not affect brain temperature. Rats were polygraphically recorded for 6 h, and brain temperature was recorded every 10 min for 3 h. Administration of 0.047 mumol ethanol increased total sleep during the 3-6 h interval, while 0.24 and 0.47 mumol ethanol increased deep slow-wave sleep (SWS2) and total sleep during the 3-6- and 0-6-h intervals. The 0.24-mumol ethanol microinjections also increased REM sleep for the 0-6-h interval. No changes in sleep latencies were observed.