An empirical test of two opposing theoretical models of prefrontal function

The purpose of this study was to compare the validity of two models which contrast with each other in the manner in which they integrate neuropsychological tests into distinct prefrontal constructs. The first prefrontal model consists of five distinct functional constructs drawn from human clinical neuropsychology. The second model, elaborated by Goldman-Rakic, is based primarily on monkey research and postulates a basic prefrontal function, "on-line representational memory," which guides behavior in the absence of, or despite discriminative environmental stimuli. In the latter model, distinct prefrontal functional constructs are primarily defined in terms of various types of representational memory involved in specific tasks. Eleven "prefrontal" measures were obtained from 259 normal adults, stratified for age, education, and sex. Confirmatory factor analyses revealed that the Goldman-Rakic model "fit" the data better than the model derived from human clinical neuropsychology, while several constructs commonly used in human neuropsychology were refuted. It was concluded that new research on brain-damaged humans with a view to understanding prefrontal function might benefit from using the Goldman-Rakic model as a starting point.