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Updated: Jul 26, 2026

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
[Autologous grafting of extraocular muscles: experimental study in rabbits]
Jorge Meireles-Teixeira1, Harley E A Bicas
1Doutorando do setor de Estrabismo, Universidade Federal de São Paulo, São Paulo, Brazil. jorgemeireles1@bol.com.br
Purpose:
To evaluate the feasibility of autologous extraocular muscle grafting as a type of muscle expansion surgery.
Methods:
The left superior rectus muscle of twenty-nine rabbits was resected and this fragment was attached to the endpoint of the respective right superior rectus (test group). Thereafter, the superior rectus of the left eye was reattached to the sclera (control group). Both groups were examined during different postoperative periods in order to assess their outcomes.
Results:
The presence of hyperemia was slightly more frequent in the grafted group. Secretion and muscle atrophy were negligible in both groups. Fibrosis was greater in grafted animals. These muscles were weaker than the control muscles, although the force required to split muscular parts was always greater than the physiological one.
Conclusions:
This surgical technique was reliable and useful if one intends to achieve muscle expansion without the intrinsic risks of dealing with heterologous/artificial materials.
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