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[Primary malignant melanomas of the nasal fossae]
S Valerdiz1, J Martín, M Coloma
1Servicio de Anatomía Patológica, Hospital Camino de Santiago, Ponferrada, León.
Abstract:
Melanoma of the nasal and paranasal sinus mucosa represented less than 1% of all melanomas. Melanoma to be localized commonly in nasal septum and your prognosis is poor. We presented three cases with a mean age of 75 years. The tumor was localized in nose. The melanocytes were presented in only case. All the tumoral cells stained with S-100 and HMB-45. In a case the vascular invasion was presented. Only a patient was treated with surgical excision. Two patients death 8 months after diagnosis.
Insights
Melanoma of the nasal and paranasal sinus mucosa is rare, often found in the nasal septum with a poor prognosis. This study highlights three elderly cases, with aggressive tumors and poor outcomes, emphasizing the need for awareness.
Area of Science:
- Oncology
- Otorhinolaryngology (ENT)
- Dermatology
Background:
- Melanoma of the nasal and paranasal sinus mucosa is a rare malignancy, accounting for less than 1% of all melanomas.
- This type of melanoma commonly presents in the nasal septum, often associated with a poor prognosis.
Observation:
- Three cases of sinonasal mucosal melanoma were analyzed, with a mean patient age of 75 years.
- Tumors were localized within the nasal cavity.
- Melanocytes were identified in only one case, while all tumoral cells stained positive for S-100 and HMB-45.
- Vascular invasion was noted in one case.
Findings:
- The study observed a high mortality rate, with two out of three patients dying approximately 8 months post-diagnosis.
- Only one patient received surgical excision as treatment.
Implications:
- This case series underscores the aggressive nature and poor prognosis of sinonasal mucosal melanoma.
- Further research into optimal treatment strategies and earlier diagnostic methods is warranted for this rare cancer.