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Updated: Aug 2, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
Published on: February 28, 2019
The peptide molecular links between the central nervous and the immune systems
I Z Siemion1, A Kluczyk, M Cebrat
1Faculty of Chemistry, University of Wrocław, Wrocław, Poland. siemion@wchuwr.chem.uni.wroc.pl
Abstract:
The central nervous system (CNS) and the immune system were for many years considered as two autonomous systems. Now, the reciprocal connections between them are generally recognized and very well documented. The links are realized mainly by various immuno- and neuropeptides. In the review the influence of the following immunopeptides on CNS is presented: tuftsin, thymulin, thymopoietin and thymopentin, thymosins, and thymic humoral factor. On the other side, the activity in the immune system of such neuropeptides as substance P, neurotensin, some neurokinins, enkephalins, and endorphins is discussed.
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