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Published on: September 15, 2011
Epileptogenesis due to peripheral injury as a cause of focal epilepsy
Allison E Spiller1, Alan Guberman, Fabrice Bartolomei
1Department of Medicine, Division of Neurology, Kingston General Hospital, Queen's University, Kingston, Canada.
Purpose:
To report three patients in whom focal epilepsy developed shortly after painful soft tissue injuries to their hands.
Methods:
Case reports.
Results:
The attacks started in the injured hand. No evidence was found of an underlying brain lesion by history or from imaging studies.
Conclusions:
These cases suggest the possibility that the injuries led to a plastic change in the sensory/motor cortex, leading to increased excitability and ultimately to seizures. This suggests that epileptogenesis can occur in response to painful peripheral stimuli in some individuals.
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