Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optical mapping of electrical activation in the developing heart.

David Sedmera1, Maria Reckova, Carlin Rosengarten

  • 1Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA. sedmerad@musc.edu

Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
|August 3, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Heterozygous Loss of Scn1b Results in Concealed Conduction Phenotype Unmasked by Osmotic Stress.

bioRxiv : the preprint server for biology·2026
Same author

Prioritizing Discovery and Advancements in Arrhythmia Therapies: NIH/NHLBI Workshop.

JACC. Clinical electrophysiology·2026
Same author

Oral connexin43-peptide-loaded milk extracellular vesicles mitigate lethal radiation injury while preserving tumour radiosensitivity.

Cancer letters·2026
Same author

Clinical Anatomy of the Left and Right Atrial Appendages in Humans: Comparative and Developmental Perspective.

Clinical anatomy (New York, N.Y.)·2026
Same author

Regeneration of the lizard heart after cryoinjury.

Experimental physiology·2026
Same author

Phospho-mimic βIII-tubulin rescues microtubule and cardiac defects in Duchenne muscular dystrophy mice.

Journal of molecular and cellular cardiology·2026

The development of the heart

Area of Science:

  • Cardiology
  • Developmental Biology
  • Physiology

Background:

  • Specialized conduction tissues coordinate electrical activity in the adult vertebrate heart.
  • The His-Purkinje system (HPS) enables rapid, apex-to-base ventricular activation.
  • Mature HPS function develops through distinct cardiac morphogenesis stages.

Purpose of the Study:

  • To investigate the developmental transition of ventricular activation patterns.
  • To determine the influence of hemodynamic loading on this transition.
  • To compare developmental timing across species.

Main Methods:

  • Utilized optical mapping to visualize cardiac electrical propagation.
  • Manipulated hemodynamic loading (pressure overload, hypoplasia).

Related Experiment Videos

  • Compared findings between chick and mammalian embryos.

    • Main Results:

    • Ventricular activation shifts from base-to-apex to apex-to-base during development.
    • This transition is accelerated by pressure overload and delayed by hypoplasia.
    • Significant interspecies similarities and differences in developmental timing were observed.

    Conclusions:

    • Hemodynamic loading critically influences the timing of mature His-Purkinje system function development.
    • Cardiac morphogenesis involves a dynamic interplay between electrical and mechanical forces.
    • Comparative studies highlight conserved and divergent pathways in cardiac conduction development.