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Related Experiment Videos

Pre-procedural ACE-activity does not predict symptomatic in-stent restenosis.

L J Wagenaar1, B M Rahel, A J van Boven

  • 1Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands.

International Journal of Cardiology
|August 3, 2005
PubMed
Summary

Angiotensin-converting enzyme (ACE) activity in plasma or atherosclerotic plaque does not predict in-stent restenosis after coronary stent placement. This finding suggests ACE activity is not a reliable biomarker for restenosis risk.

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Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Interventional Cardiology

Background:

  • Atherosclerosis is linked to Angiotensin-Converting Enzyme (ACE) activity.
  • The role of ACE activity in in-stent restenosis remains unclear.

Purpose of the Study:

  • To investigate the correlation between ACE activity in plasma and atherosclerotic plaque with in-stent restenosis.
  • To determine if pre-procedural ACE activity can predict adverse clinical events post-stenting.

Main Methods:

  • ACE activity was measured in plasma samples from 178 patients undergoing percutaneous coronary intervention with stent placement.
  • ACE content was assessed immunohistologically in plaque tissue from 13 patients with de novo stenosis.
  • Follow-up included clinical events and quantitative coronary angiography.

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Main Results:

  • No significant difference in plasma ACE activity was observed between patients with and without adverse clinical events (P=0.36).
  • ACE content in atherosclerotic plaque tissue did not correlate with late luminal loss after 12 months (P=0.76).

Conclusions:

  • Pre-procedural plasma ACE activity does not predict in-stent restenosis.
  • ACE activity within atherosclerotic plaque also does not predict restenosis.
  • ACE activity is not a reliable predictor of in-stent restenosis in this study cohort.