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Updated: Aug 16, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
12:03

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors

Published on: June 7, 2016

Angiotensin receptors: a new role in cancer?

Frédérique Deshayes1, Clara Nahmias

  • 1Institut Cochin, CNRS UMR8104-INSERM U567, Departement de Biologie Cellulaire, 22 rue Méchain, 75014 Paris, France.

Trends in Endocrinology and Metabolism: TEM
|August 3, 2005
PubMed

Insights

Angiotensin II (AngII) plays a role in cancer by influencing cell growth and blood vessel formation. Angiotensin I-converting enzyme (ACE) inhibitors and receptor blockers show potential in cancer treatment.

Area of Science:

  • Cardiovascular Science
  • Oncology
  • Molecular Biology

Background:

  • Angiotensin II (AngII) is a key regulator of blood pressure and cardiovascular homeostasis.
  • Emerging evidence links AngII to cell proliferation, angiogenesis, inflammation, and tissue remodeling, suggesting a role in cancer.
  • The Angiotensin I-converting enzyme (ACE) and its receptors are implicated in various cancer aspects.

Purpose of the Study:

  • To review the expression and function of ACE and AngII receptors in cancer.
  • To explore the role of AngII type 1 receptor (AT1R) and AngII type 2 receptor (AT2R) in tumor progression.
  • To overview intracellular signaling pathways activated by AT1R and AT2R in cancer.

Main Methods:

  • Literature review of experimental data on ACE inhibitors and AngII receptor antagonists.
  • Analysis of studies investigating AT1R and AT2R roles in tumor vascularization and metastasis.
  • Examination of signaling pathways in cancer, endothelial, and inflammatory cells.

Main Results:

  • ACE inhibitors and AT1R antagonists demonstrate beneficial effects on tumor progression, vascularization, and metastasis.
  • The AT2R subtype shows potential involvement in cancer development.
  • Specific intracellular signaling pathways associated with AT1R and AT2R activation are identified.

Conclusions:

  • The renin-angiotensin system, particularly AngII and its receptors, is significantly involved in cancer biology.
  • Targeting ACE and AngII receptors presents a promising therapeutic strategy for cancer treatment.
  • Further research into AT2R's role and detailed signaling mechanisms is warranted for comprehensive cancer therapy development.

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