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Randomised trial of telephone intervention in chronic heart failure: DIAL trial
Insights
A centralized telephone intervention significantly reduced hospital admissions for worsening heart failure in outpatients. This effective heart failure management program improved patient quality of life without increasing mortality.
Area of Science:
- Cardiology
- Public Health
- Telemedicine
Background:
- Chronic heart failure (CHF) is a leading cause of hospital admissions.
- Effective outpatient management strategies are crucial for improving CHF patient outcomes.
- Telephone-based interventions offer a scalable approach to patient monitoring and support.
Purpose of the Study:
- To evaluate the efficacy of a centralized telephone intervention in reducing death or hospital admission for worsening heart failure.
- To assess the impact of this intervention on patient quality of life.
Main Methods:
- A multicenter randomized controlled trial involving 1518 outpatients with stable chronic heart failure.
- Patients were randomized to receive either usual care or a telephone intervention including education, counseling, and monitoring.
- The primary outcome was all-cause mortality or hospital admission for worsening heart failure.
Main Results:
- The telephone intervention group showed a 20% relative risk reduction in the primary endpoint (death or hospital admission for heart failure) compared to usual care (26.3% vs. 31%).
- A significant reduction in heart failure admissions (29% relative risk reduction) was observed in the intervention group.
- Patients receiving the telephone intervention reported a better quality of life.
Conclusions:
- A simple, centralized telephone intervention program is effective in reducing hospital admissions for heart failure.
- This approach improves patient outcomes and quality of life in chronic heart failure management.
- Telephone-based care represents a valuable strategy for managing heart failure patients in outpatient settings.
Objective:
To determine whether a centralised telephone intervention reduces the incidence of death or admission for worsening heart failure in outpatients with chronic heart failure.
Design:
Multicentre randomised controlled trial.
Setting:
51 centres in Argentina (public and private hospitals and ambulatory settings).
Participants:
1518 outpatients with stable chronic heart failure and optimal drug treatment randomised, stratified by attending cardiologist, to telephone intervention or usual care.
Intervention:
Education, counselling, and monitoring by nurses through frequent telephone follow-up in addition to usual care, delivered from a single centre.
Main Outcome Measure:
All cause mortality or admission to hospital for worsening heart failure.
Results:
Complete follow-up was available in 99.5% of patients. The 758 patients in the usual care group were more likely to be admitted for worsening heart failure or to die (235 events, 31%) than the 760 patients who received the telephone intervention (200 events, 26.3%) (relative risk reduction = 20%, 95% confidence interval 3 to 34, P = 0.026). This benefit was mostly due to a significant reduction in admissions for heart failure (relative risk reduction = 29%, P = 0.005). Mortality was similar in both groups. At the end of the study the intervention group had a better quality of life than the usual care group (mean total score on Minnesota living with heart failure questionnaire 30.6 v 35, P = 0.001).
Conclusions:
This simple, centralised heart failure programme was effective in reducing the primary end point through a significant reduction in admissions to hospital for heart failure.
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