Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain-derived neurotrophic factor in amygdala-dependent learning.

Lisa M Rattiner1, Michael Davis, Kerry J Ressler

  • 1Emory University School of Medicine, Department of Psychiatry, Center for Behavioral Neuroscience, Atlanta, Georgia 30329, USA.

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
|August 3, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defining the <i>r</i> factor for post-trauma resilience and its neural predictors.

Nature. Mental health·2025
Same author

Rare coding mutations identify 36 large-effect risk genes in obsessive-compulsive disorder and chronic tic disorders.

medRxiv : the preprint server for health sciences·2025
Same author

Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.

Nature. Mental health·2025
Same author

Post-traumatic stress and genetic interactions affect tobacco and alcohol use after trauma: findings from a multi-ancestry cohort.

Translational psychiatry·2025
Same author

Correspondence between sleep patterns and anhedonia in adult male mice exposed to early-life stress.

Translational psychiatry·2025
Same author

Identification of an intrusive-hypervigilant phenotype of posttraumatic stress symptoms with unique stress peptide and amygdala functional connectivity profiles.

medRxiv : the preprint server for health sciences·2025

Brain-derived neurotrophic factor (BDNF) is key for learning and memory. Research using fear conditioning in the amygdala offers new insights into BDNF

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Behavioral Science

Background:

  • Brain-derived neurotrophic factor (BDNF) is implicated in synaptic plasticity, crucial for learning and memory.
  • Hippocampal models of long-term potentiation (LTP) have been used to study BDNF's role, but hippocampal circuitry complexity limits understanding.
  • The amygdala and Pavlovian fear conditioning offer a simpler neural circuit to investigate BDNF's function in memory.

Purpose of the Study:

  • To review research on BDNF's role in learning and memory.
  • To highlight the utility of Pavlovian fear conditioning for studying BDNF in the amygdala.
  • To explore BDNF-mediated synaptic plasticity within a well-defined neural circuit.

Main Methods:

  • Review of existing literature on BDNF, learning, and memory.

Related Experiment Videos

  • Focus on studies utilizing Pavlovian fear conditioning as a model system.
  • Examination of BDNF's role in the amygdala following a single learning event.

    • Main Results:

    • BDNF is a critical molecular mediator of activity-dependent synaptic plasticity.
    • Pavlovian fear conditioning in the amygdala provides a tractable model for studying BDNF.
    • Understanding BDNF's function in the amygdala can elucidate memory formation mechanisms.

    Conclusions:

    • The amygdala's role in fear conditioning is a promising model for dissecting BDNF's function in learning and memory.
    • Further research using this model can unravel the molecular basis of memory.
    • BDNF is central to synaptic plasticity underlying memory processes.