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Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach
Published on: December 1, 2011
Determination of co-receptor usage of HIV-1
Hanneke Schuitemaker1, Neeltje A Kootstra
1Department of Clinical Viro-Immunology Sanquin Research at CLB, Academical Medical Center, Amsterdam, The Netherlands.
Methods in Molecular Biology (Clifton, N.J.)
|August 3, 2005
Abstract:
In addition to CD4, HIV-1 uses chemokine receptors for entry in their target cells. The most important chemokine receptors in this respect are beta-chemokine receptor 5 (CCR5) and alpha-chemokine receptor 4 (CXCR4). Coreceptor usage is an important feature of the biological phenotype of HIV-1 variants. In this chapter, methods are described to determine the co-receptor usage of HIV-1 variants.

