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Carbohydrate metabolism in Down's syndrome.

K Yasuda, T Sakurada, M Yamamoto

    The Tohoku Journal of Experimental Medicine
    |December 1, 1979
    PubMed
    Summary

    Obesity may contribute to impaired glucose tolerance in Down

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    Area of Science:

    • Endocrinology and Metabolism
    • Human Genetics and Disease

    Background:

    • Down's syndrome (Trisomy 21) is associated with various health complications.
    • Understanding carbohydrate metabolism in individuals with Down's syndrome is crucial for managing associated health risks.

    Purpose of the Study:

    • To investigate carbohydrate metabolism in pediatric patients with Down's syndrome.
    • To identify factors contributing to glucose intolerance in this population.

    Main Methods:

    • Oral glucose tolerance tests were performed on eight patients aged 8-18 years with Down's syndrome.
    • Insulin response and free fatty acid levels were measured.
    • Body mass and weight changes were monitored.

    Main Results:

    • One obese patient exhibited diabetic glucose tolerance, which improved with weight reduction.
    • Two patients showed flat glucose tolerance curves with low peak values.
    • Five patients had normal glucose tolerance; insulin and free fatty acid levels were generally unremarkable, except in the obese diabetic patient.

    Conclusions:

    • Obesity appears to be a significant factor in impaired glucose tolerance among individuals with Down's syndrome.
    • Further research is warranted to explore the metabolic profile in Down's syndrome, considering factors like obesity.

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