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Cryopreserved vein transplantation.

K G Brockbank1, R T McNally, K A Walsh

  • 1CryoLife, Inc., Marietta, Georgia 30067.

Journal of Cardiac Surgery
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

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Cryopreserved saphenous veins show promise for arterial bypass. Experimental studies confirm cryopreservation doesn't harm vein graft function, while clinical results show encouraging patency rates.

Area of Science:

  • Vascular Surgery
  • Biomaterials Science
  • Immunology

Background:

  • Arterial bypass surgery often uses prosthetic conduits or autograft saphenous veins.
  • Cryopreserved allograft saphenous veins are an alternative being investigated for arterial reconstruction.

Purpose of the Study:

  • To summarize experimental and clinical findings on cryopreserved allograft saphenous veins for arterial bypass.
  • To evaluate the impact of cryopreservation and storage on vein graft viability and function.

Main Methods:

  • Experimental studies on cryopreserved autografts and allografts.
  • Assessment of graft patency, arterialization, blood flow, and platelet deposition.
  • Evaluation of endothelial function and immune response in allografts.
  • Clinical follow-up of patients receiving cryopreserved allograft saphenous vein grafts.

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Main Results:

  • Cryopreservation did not negatively affect autograft patency, arterialization, blood flow, or platelet deposition.
  • Cryopreserved autografts maintained endothelial-derived relaxing and contractile factor production.
  • In allografts, endothelium was lost within 10 days due to immune response, with minimal fibrin deposition.
  • Re-endothelialization of allografts occurred over 6-9 months.
  • 1-year patency rates were 79% for peripheral and 86% for coronary bypass grafts.

Conclusions:

  • Cryopreservation is a viable method for storing saphenous veins for arterial bypass.
  • Cryopreserved allograft saphenous veins demonstrate promising early clinical outcomes for both peripheral and coronary bypass.
  • Further research into optimizing allograft survival and integration is warranted.