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Related Experiment Videos

Ureteral replacement with a new prosthesis.

B Schreiber, W Homann, M Mlynek

    Transactions - American Society for Artificial Internal Organs
    |January 1, 1979
    PubMed
    Summary
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    A novel flexible silicone ureteral prosthesis and implantation technique show promise in pigs. The device effectively drained urine for up to 12 months without complications, suggesting potential for human clinical trials.

    Area of Science:

    • Biomaterials Science
    • Urology
    • Surgical Innovation

    Background:

    • Ureteral prostheses are crucial for managing urinary tract obstructions.
    • Current alternatives like nephrostomy have limitations.
    • Development of improved, long-lasting ureteral prostheses is needed.

    Purpose of the Study:

    • To evaluate a new flexible silicone ureteral prosthesis.
    • To assess a novel implantation technique in a preclinical model.
    • To determine the safety and efficacy of the prosthesis for urine drainage.

    Main Methods:

    • A new flexible silicone ureteral prosthesis was developed.
    • An improved implantation technique was utilized in 20 miniature pigs.
    • Prosthesis performance and complications were monitored for up to 12 months.

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    Main Results:

    • All prostheses remained securely in place.
    • Adequate drainage of the upper urinary collecting system was achieved.
    • No instances of leakage, incrustation, dislocation, or rejection were observed.

    Conclusions:

    • The novel silicone ureteral prosthesis and implantation technique are safe and effective in miniature pigs.
    • The prosthesis demonstrates excellent biocompatibility and durability.
    • Results support further investigation for human clinical application as an alternative to nephrostomy.