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Related Experiment Videos

Eye movements in myotonic dystrophy.

E Bollen1, J C den Heyer, M H Tolsma

  • 1Department of Neurology, University Hospital Leiden, The Netherlands.

Brain : a Journal of Neurology
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

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Patients with myotonic dystrophy show reduced smooth pursuit eye movement gain. This finding, alongside normal saccadic eye movements, suggests periventricular white matter abnormalities may explain the impaired visual tracking in this neuromuscular disorder.

Area of Science:

  • Ophthalmology
  • Neurology
  • Genetics

Background:

  • Myotonic dystrophy is a multisystem disorder.
  • Eye movement abnormalities are common in myotonic dystrophy.
  • The underlying cause of impaired smooth pursuit in myotonic dystrophy is not fully understood.

Purpose of the Study:

  • To investigate smooth pursuit eye movements in patients with myotonic dystrophy.
  • To explore potential explanations for reduced smooth pursuit gain.

Main Methods:

  • Infrared reflection oculography was used to record eye movements.
  • Smooth pursuit gain was measured in 10 patients with myotonic dystrophy and 10 controls.
  • Analysis included correction for catch-up saccades and evaluation of saccadic latencies and fixation.

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Main Results:

  • Patients with myotonic dystrophy exhibited significantly decreased smooth pursuit gain compared to controls.
  • Normal saccadic eye movement latencies and fixation suggest attention and extra-ocular muscle function are unlikely causes.
  • The presence of catch-up saccades was noted in the patient group.

Conclusions:

  • Reduced smooth pursuit gain in myotonic dystrophy is likely not due to attention deficits or extra-ocular myopathy.
  • Periventricular white matter abnormalities are proposed as a more probable explanation for impaired smooth pursuit in myotonic dystrophy.
  • Further research into the neuroanatomical correlates of visual tracking deficits in myotonic dystrophy is warranted.