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Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
New chromosomal abnormality. t(1;19;?) in a case of B-chronic lymphocytic leukemia
S Montero1, M R Caballín, M D Coll
1Department of Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, Spain.
Abstract:
Cytogenetic analysis was performed on peripheral blood cells stimulated with interleukin 6 (IL-6), lipopolysaccharide from Escherichia coli (LPS), phytohemagglutinin (PHA), pokeweed mitogen (PWM) and tetradecanoyl-phorbol-acetate (TPA), in a patient with B-chronic lymphocytic leukemia, showing a t(1;19;?) translocation as the sole abnormality. To our knowledge, this translocation has not been described before in any human neoplasia. In this case, the poor response to therapy (survival time 4 months) suggested that t(1;19;?) could be related to an aggressive course of the disease.
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