Rapid development of the auditory brainstem response threshold in individual ferrets

The development of the ferret auditory system was examined using the auditory brainstem response (ABR). Longitudinal recordings were obtained under short-acting anaesthesia from individual animals at 4-h or 24-h intervals. Particular attention was focused on the period from postnatal day (P) 26 to P32 when the ferret auditory system becomes functional. ABR thresholds to click stimuli presented in a free-field were found to decline precipitously within a 4-h period during the first 24 h following initial responsiveness. Latencies of waves I and IV of the ABR also declined significantly during this period, but the 'central conduction time' remained stable. A temporal correlation was observed between the time of the precipitous threshold decline and the time of opening of the external ear canal. No changes in cochlear anatomy were observed during this time. We suggest that the opening of the ear canal and/or the clearance of fluid from the middle ear explain the major change in threshold of hearing following onset of function.