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Updated: Sep 25, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice
Published on: January 25, 2016
[The hexobarbital sleeping time in a pharmacologico-toxicological experiment with special reference to age and
N Lange1, M Kühnert, F Ebbinghaus
1Institut für Pharmakologie, Pharmazie und Toxikologie der Veterinärmedizinischen Fakultät der Universität Leipzig.
Abstract:
Investigations were performed to determine the hexobarbital sleeping time (HST) of a strain of Wistar rats (WIST/Lppt). Another aim of the studies was to demonstrate possibilities to use the HST as a method to get additional informations during pharmacological and toxicological experiments. The age--and sex--dependent changes in the hexobarbital sleeping time of the investigated strain of rats are in coincidence with results of other authors, using different rat strains. Additionally, the HST more or less depends on circadian and circannual rhythm. It was stated that the HST as a prescreening-method before starting investigations in detail is of great importance.
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