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Updated: Aug 10, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
Abstract:
The dilation of the femoral vein during pregnancy was analysed retrospectively in patients with unilateral severe varicose veins (group I, n = 7), mild varicose veins (group II, n = 8) and healthy pregnant women (group III, n = 3). Groups I and II employed elastic stockings as treatment, while group I additionally applied a ruscus-containing cream to the affected leg. In the healthy women, in the unaffected leg in group II and in the cream treated leg in group I, the femoral vein increased in diameter on average by 2.1 to 2.4 mm in the third term of pregnancy, while in the affected leg of group II it increased by 3.6; in group I the increase in the leg not treated with cream was about 4.5 mm. The differences in dilatation are significant (p less than 0.05). Apparently, the venous tonic action of ruscus extract can considerably reduce venous dilatation during pregnancy.
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