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Genital benign chronic pemphigus (Hailey-Hailey disease) presenting as condylomas
A Langenberg1, T G Berger, M Cardelli
1Department of Dermatology, University of California, San Francisco.
Journal of the American Academy of Dermatology
|June 1, 1992
Summary
Verrucous genital lesions can be a sign of benign chronic pemphigus (BCP), also known as Hailey-Hailey disease. Histologic examination is key to differentiating BCP from other conditions like genital warts.
Area of Science:
- Dermatology
- Pathology
Background:
- Benign chronic pemphigus (BCP), or Hailey-Hailey disease, can manifest as verrucous papules on the genitalia.
- Differential diagnosis for these lesions includes genital warts and papular acantholytic dyskeratosis.
Observation:
- A study examined six patients (five female, one male) with verrucous anogenital lesions initially diagnosed as warts.
- Lesions were primarily located in the perineal and perianal areas; one patient also had axillary involvement.
- Family history was negative in half of the cases.
Findings:
- Histologic examination confirmed BCP in all cases.
- Characteristic findings included the absence of crusts and minimal inflammation.
- Verrucous morphology was noted in these genital lesions.
Implications:
- Verrucoid genital lesions with histologic features of Hailey-Hailey disease may represent BCP.
- Accurate diagnosis is crucial for appropriate patient management.
- This highlights the importance of considering BCP in the differential diagnosis of anogenital verrucous lesions.