Related Experiment Video
Updated: Aug 11, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Genital benign chronic pemphigus (Hailey-Hailey disease) presenting as condylomas
A Langenberg1, T G Berger, M Cardelli
1Department of Dermatology, University of California, San Francisco.
Background:
Genital lesion sof benign chronic pemphigus (FBCP)(Hailey-Hailey disease) may present as verrucous papules. Genital warts and papular acantholytic dyskeratosis of the genitalia may be considered in the differential diagnosis.
Objective:
Our purpose was to describe the clinical characteristics and histologic features of verrucous anogenital FBCP.
Methods:
Six patients, five women and one man, with verrucous anogenital lesions of FBCP, initially diagnosed as warts, were examined and biopsy specimens were evaluated histologically.
Results:
The lesions were located exclusively in the perineal and perianal regions with axillary involvement in one case. Family history was negative in three of the six cases. Histologic examination confirmed the diagnosis of FBCP but was significant for the absence of crusts and the presence of only minimal inflammation.
Conclusion:
Our cases and the literature are reviewed with the conclusion that all verrucoid genital lesions with the histologic characteristics of Hailey-Hailey disease may represent FBCP.
Related Concept Videos
Sexually Transmitted Infections
Herpes
Chickenpox
Genital Herpes
Candidiasis
Trichomoniasis

