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Lipoatrophic diabetes.

T Sasaki1, H Ono, H Nakajima

  • 1Department of Dermatology, Yokohama City University School of Medicine, Japan.

The Journal of Dermatology
|April 1, 1992
PubMed
Summary

This case report details a patient with acanthosis nigricans and insulin resistant diabetes who later developed generalized lipoatrophy. The findings highlight the importance of skin examination for diagnosing lipoatrophic diabetes.

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Area of Science:

  • Endocrinology
  • Dermatology
  • Metabolic Disorders

Background:

  • Lipoatrophic diabetes is a rare syndrome characterized by insulin resistance, acanthosis nigricans, and generalized lipoatrophy.
  • Early diagnosis and management are crucial for preventing severe metabolic complications.

Observation:

  • A female patient presented with acanthosis nigricans and insulin resistant diabetes at age 36, with symptoms including arthralgia, muscle weakness, and peripheral neuropathy.
  • Generalized lipoatrophy became prominent around age 47.
  • Insulin receptor studies excluded insulin resistant diabetes types A and B.

Findings:

  • The patient was diagnosed with lipoatrophic diabetes, a syndrome encompassing insulin resistant diabetes, acanthosis nigricans, and generalized lipoatrophy.
  • Diabetes control remained poor, with persistent diabetic neuropathy and painful skin lesions due to lipoatrophy.

Implications:

  • This case underscores the critical role of thorough skin examinations in identifying lipoatrophic diabetes.
  • Recognizing the dermatological manifestations can lead to earlier diagnosis and improved management of this complex metabolic disorder.

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