Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Targeting endothelial dysfunction in hypertensive subjects.

C Thuillez1, V Richard

  • 1Department of Pharmacology, Rouen University Hospital, Rouen, France. Christian.Thuillez@chu-rouen-fr

Journal of Human Hypertension
|August 3, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: The mineralocorticoid receptor antagonist finerenone enhances cardiovascular recovery upon food intake normalization in obese mice.

Cardiovascular diabetology·2026
Same author

Impact of blood transfusion on survival after nephrectomy for localized or locally advanced renal cancer.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2022
Same author

[Thrombin generation assay in autoimmune disease].

La Revue de medecine interne·2021
Same author

New insights into antiphospholipid-related endothelial dysfunction by assessment of vascular glycocalyx layer: results from a preliminary cross-sectional study.

Lupus·2020
Same author

[Concordances and predictors of biopsies in renal tumors].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2019
Same author

Mosquito vectors of arboviruses in French Polynesia.

New microbes and new infections·2019
Same journal

Patient out-of-pocket costs for antihypertensive single pill combination products with cost caps.

Journal of human hypertension·2026
Same journal

Mindfulness based interventions for blood pressure reduction: systematic and umbrella review of existing meta-analyses.

Journal of human hypertension·2026
Same journal

Invasive observation of reactive systolic blood pressure responses to upper-arm cuff inflation.

Journal of human hypertension·2026
Same journal

Association between post-thrombectomy blood pressure trajectories and clinical outcomes in hypertensive patients with acute ischemic stroke: a retrospective cohort study.

Journal of human hypertension·2026
Same journal

Systemic inflammation indices generated from first-trimester blood tests can be potential biomarkers for predicting preeclampsia.

Journal of human hypertension·2026
Same journal

Chronotherapy in hypertension: a systematic review and meta-analysis of antihypertensive dosing timing on cardiovascular outcomes.

Journal of human hypertension·2026
See all related articles

Hypertension damages the endothelium, impairing blood vessel function. Certain antihypertensive drugs improve endothelial function by boosting nitric oxide (NO) and reducing oxidative stress.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Pharmacology

Background:

  • The endothelium plays a crucial role in cardiovascular health, acting as an early target for risk factors like hypertension.
  • Endothelial dysfunction in hypertension contributes to atherosclerosis and target-organ damage through altered vasomotor tone, arterial stiffness, and inflammation.
  • Dysfunction involves increased nitric oxide (NO) degradation and potentially decreased NO production, highlighting the need for clinical evaluation.

Purpose of the Study:

  • To evaluate the impact of different antihypertensive drug classes on endothelial function.
  • To understand the mechanisms by which these drugs affect endothelial health in hypertension.
  • To emphasize the clinical significance of assessing endothelial function in hypertensive patients.

Main Methods:

Related Experiment Videos

  • Review of studies examining endothelial function in hypertensive patients and experimental models.
  • Analysis of the effects of various antihypertensive drug classes, including ACE inhibitors, AT1 blockers, calcium antagonists, and beta-blockers.
  • Assessment of changes in endothelium-dependent vasodilatation, nitric oxide (NO) bioavailability, and oxidative stress markers.

Main Results:

  • Angiotensin-converting enzyme inhibitors, perindopril-indapamide, and AT1 receptor blockers improve endothelium-dependent vasodilatation, partly independent of blood pressure reduction, via antioxidant effects and NO release.
  • Recent calcium antagonists show improvements in endothelial function and oxidative stress markers.
  • Most beta-blockers do not affect endothelial function; nebivolol improves it through NO donation, not beta-blockade.

Conclusions:

  • Certain antihypertensive medications offer significant benefits for endothelial function beyond blood pressure control.
  • Targeting endothelial dysfunction with specific drug classes is crucial for managing hypertension and preventing cardiovascular events.
  • Nebivolol stands out among beta-blockers for its positive impact on endothelial health via nitric oxide pathways.