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Infantile case of occlusive microvascular retinopathy after bone marrow transplantation

Eriko Kawase1, Noriyuki Azuma, Yoko Shioda

  • 1Department of Ophthalmology, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan. kawase@eye-center.org

Japanese Journal of Ophthalmology
|August 3, 2005
PubMed

Insights

Retinal complications, such as occlusive microvascular retinopathy, are rare in infants after bone marrow transplantation (BMT). Oral prednisolone effectively treated neovascularization in an infant, but visual prognosis depends on foveal involvement.

Area of Science:

  • Ophthalmology
  • Pediatric Hematology-Oncology
  • Transplantation Medicine

Background:

  • Ocular complications post-bone marrow transplantation (BMT) are documented in adults and children.
  • Retinal complications in infants following BMT are rarely reported, highlighting a knowledge gap.

Observation:

  • A 6-month-old infant developed occlusive microvascular retinopathy after BMT for acute lymphocytic leukemia.
  • Fundus examination revealed retinal edema, hemorrhage, soft exudates, and neovascularization in both eyes.

Findings:

  • Treatment with oral prednisolone led to regression of retinal lesions.
  • Post-treatment cicatrices included chorioretinal atrophy and fibrous tissue formation.

Implications:

  • Neovascularization secondary to occlusive microvascular retinopathy in infants post-BMT demonstrates a positive response to oral prednisolone.
  • Visual outcomes are contingent upon the extent of foveal involvement in the retinopathy.
Abstract

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