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Related Experiment Videos

Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis.

S Anand Trip1, Patricio G Schlottmann, Stephen J Jones

  • 1NMR Research Unit, Department of Neuroinflammation, Brain Injury and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom. a.trip@ion.ucl.ac.uk

Annals of Neurology
|August 3, 2005
PubMed
Summary

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Noninvasive optical coherence tomography can detect axonal loss in the retinal nerve fiber layer after optic neuritis. This method may help track disability and test new treatments for multiple sclerosis.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Medical Imaging

Background:

  • Persistent disability after multiple sclerosis (MS) relapses is often linked to axonal loss.
  • Noninvasive in vivo markers are crucial for quantifying axonal damage in MS.
  • Optic neuritis serves as a relevant model for studying MS-related axonal injury.

Purpose of the Study:

  • To quantify axonal loss in the retinal nerve fiber layer (RNFL) and retinal ganglion cell loss in the macula following optic neuritis using optical coherence tomography (OCT).
  • To establish relationships between RNFL thickness and visual function.
  • To evaluate the potential of RNFL imaging as a biomarker in clinical trials.

Main Methods:

  • A cohort of 25 patients with a history of optic neuritis and 15 healthy controls were studied.

Related Experiment Videos

  • Optical coherence tomography was used to measure RNFL thickness and macular volume.
  • Quantitative visual testing and electrophysiological assessments were performed.

    • Main Results:

    • Significantly reduced RNFL thickness and macular volume were observed in affected eyes compared to controls and unaffected fellow eyes (p < 0.001).
    • RNFL thickness showed significant correlations with visual acuity, visual field, color vision, and visual-evoked potential amplitude.
    • These findings indicate functionally relevant axonal and retinal ganglion cell loss post-optic neuritis.

    Conclusions:

    • Noninvasive OCT imaging of the RNFL can detect and quantify axonal loss after optic neuritis.
    • This technique provides a valuable tool for assessing visual pathway damage in MS.
    • RNFL imaging holds promise for use in clinical trials evaluating neuroprotective therapies for MS.