[Factors facilitating development of degenerative aortic valvular stenosis]

Area of Science:

• Cardiology
• Biochemistry
• Immunology

Background:

• Aortic valvular calcinosis (AVC) and aortic ostium stenosis (AOS) are significant cardiovascular conditions.
• Understanding their risk factors and progression is crucial for patient management.

Purpose of the Study:

• To identify risk factors and progression determinants for AVC and AOS.
• To investigate the roles of lipid metabolism, mineral metabolism, and immune status.

Main Methods:

• Analysis of lipid and mineral metabolism in 85 patients with AVC.
• Immunological tests including C-reactive protein (CRP), fibrinogen, and interleukins (IL-6, IL-8).
• Assessment of extracellular matrix synthesis and degradation markers.

Main Results:

• Key risk factors for AVC include age, osteoporosis, mitral ring calcification, dyslipidemia, extracellular matrix imbalance, and inflammation (CRP, fibrinogen, IL-6).
• AOS factors comprise age, smoking, osteoporosis, AVC, mitral ring calcification, dyslipidemia, extracellular matrix degradation, and inflammation (CRP, fibrinogen, IL-6, IL-8).
• Atherogenic dyslipidemia and mineral dysmetabolism significantly contribute to AVC; immune changes suggest inflammation's role in AVS.

Conclusions:

• Dyslipidemia and mineral metabolism disorders are primary drivers of AVC.
• Inflammation plays a critical role in the development and progression of aortic valvular stenosis (AVS).
• Age and osteoporosis are common risk factors for both AVC and AOS.