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On maximum human life span: interdisciplinary approach about its limits.

A Ruiz-Torres1, W Beier

  • 1University Research Institute of Gerontology and Metabolism, Madrid, Spain. iuigm.hlpr@salud.madrid.org

Advances in Gerontology = Uspekhi Gerontologii
|August 4, 2005
PubMed
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Human life span appears limited to approximately 120 years, based on mathematical models of human growth and aging. Factors influencing growth processes could potentially extend this maximum human lifespan.

Area of Science:

  • Gerontology
  • Biogerontology
  • Human Longevity Research

Background:

  • Investigates the theoretical maximum human lifespan.
  • Considers biological changes over the last century: increased longevity and height.

Purpose of the Study:

  • To determine the maximum potential human lifespan.
  • To explore the relationship between growth, aging, and life extension.

Main Methods:

  • Utilized demographic data and Gompertz mathematical models for growth and survival.
  • Adapted equations using normal body growth and in vitro cell growth parameters.
  • Analyzed cell proliferation, migration, and senescence in relation to donor age.

Main Results:

  • Mathematical models suggest a maximum human lifespan around 120 years.

Related Experiment Videos

  • In vitro smooth muscle cell proliferation cessation occurred at a mean donor age of 110.16 years.
  • IGF-1 extended cell growth cessation to approximately 126.4 years.

    • Conclusions:

    • Human lifespan is theoretically limited to approximately 120 years.
    • Modulating growth processes may offer potential for lifespan extension.