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[Influence of Xinqin tablets on guinea-pig nasal hypersensitivity]
Rong Zhang1, Yan Yu, Jun-rong Du
1West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Objective:
To study the influence of Xinqin tablets on guinea-pig nasal hypersensitivity.
Method:
2,4-Toluene Diisocyanate (TDI) was selected as antigen and used in nose to establish guinea-pig allergic rhinitis. The effects of Xinqin tablets on symptoms of nasal hypersensitivity in guinea-pigs, histamine content of nasal mucosa and activity of nitric oxide synthase (NOS) were examined.
Result:
Xinqin tablets could significantly relieve the pathological symptoms of nasal hypersensitivity in guinea-pig, reduce histamine content of nasal mucosa and inhibit the activity of nitric oxide synthase.
Conclusion:
Xinqin tablets have significant effect on nasal hypersensitivity, and prevent the occurrence of allergic rhinitis.
