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[Dermatomyositis/polymyositis associated with head and neck malignancy].

Wen Liu1, Zhiqiang Gao, Daofeng Ni

  • 1Department of Otorhinolaryngology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. liuwen1972@163.com

Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology
|August 4, 2005
PubMed
Summary

Dermatomyositis/polymyositis patients have a higher risk of head and neck cancers, particularly nasopharyngeal carcinoma. Early endoscopic screening is recommended for these patients to detect potential malignancies.

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Area of Science:

  • Rheumatology
  • Oncology
  • Otolaryngology

Context:

  • Dermatomyositis/polymyositis (DM/PM) is a rare idiopathic inflammatory myopathy.
  • An association between DM/PM and malignancy has been reported.
  • The specific link between DM/PM and head and neck cancers requires further elucidation.

Purpose:

  • To investigate the relationship between dermatomyositis/polymyositis and the occurrence of head and neck malignancies.
  • To identify the types of head and neck cancers associated with DM/PM.
  • To determine the incidence of head and neck malignancy in DM/PM patients.

Summary:

  • A 10-year retrospective study of 136 DM/PM patients identified 17 cases of malignancy.
  • Of these, 6 cases (35.29%) were head and neck malignancies, including nasopharyngeal carcinoma, non-Hodgkin lymphoma, and hypopharynx carcinoma.

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  • Nasopharyngeal carcinoma was the most common head and neck cancer observed.
  • Impact:

    • Nasopharyngeal carcinoma is the leading neoplasm associated with DM/PM.
    • Routine nasal endoscopic and/or fibrolaryngoscopic examinations are crucial for early detection of head and neck malignancies in all DM/PM patients.
    • This study highlights the importance of a multidisciplinary approach in managing DM/PM patients at risk for cancer.