Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Creatinine versus specific gravity-adjusted urinary cadmium concentrations.

Y Suwazono1, A Akesson, T Alfvén

  • 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. suwa@faculty.chiba-u.jp

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|August 4, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preterm Supraglottic Airways Succeed in Neonatal Resuscitation Simulations.

Acta paediatrica (Oslo, Norway : 1992)·2025
Same author

Accuracy of transvaginal ultrasound versus MRI in the PreOperative Diagnostics of low-grade Endometrial Cancer (PODEC) study: a prospective multicentre study.

Clinical radiology·2022
Same author

Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations.

Environmental research·2022
Same author

The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury.

Osteoarthritis and cartilage·2022
Same author

Impact of lymphadenectomy and lymphoedema on health-related quality of life 1 year after surgery for endometrial cancer. A prospective longitudinal multicentre study.

BJOG : an international journal of obstetrics and gynaecology·2021
Same author

Incidence of distal radius fracture in a general population in southern Sweden in 2016 compared with 2001.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same journal

A study on the prognosis of patients with sepsis or septic shock based on plasma proenkephalin levels: a meta-analysis.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2026
Same journal

Potential time-sensitive biomarkers for the detection of acute mesenteric ischaemia: a systematic review of animal data.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2026
Same journal

Tissue expression profiles of miR-6809 and miR-4753 in triple-negative breast cancer: Novel biomarkers of early detection and staging.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2026
Same journal

Digital biomarkers in non-communicable diseases.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2026
Same journal

Quantitative analysis of murine C-terminal alpha-1-antitrypsin peptides in experimental sepsis and their comparison with human sepsis peptide biomarkers.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2026
Same journal

Depression and oxidative stress in pregnancy: a cross-sectional study of trimester-specific changes.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2026
See all related articles

Urinary creatinine adjustment for cadmium levels is significantly influenced by age, gender, body size, and meat intake. Specific gravity adjustment is often more appropriate for comparing individuals with varying muscle mass or dietary habits.

Area of Science:

  • Environmental Health
  • Toxicology
  • Biomonitoring

Background:

  • Urinary cadmium levels are often adjusted for creatinine or specific gravity to account for urine dilution.
  • Factors like age, gender, body size, and diet can influence urinary creatinine concentrations.
  • Understanding these influences is crucial for accurate cadmium exposure assessment.

Purpose of the Study:

  • To evaluate the impact of age, gender, body size, and meat intake on urinary creatinine.
  • To determine how these factors affect creatinine-adjusted urinary cadmium measurements.
  • To compare the suitability of creatinine versus specific gravity for adjusting urinary cadmium.

Main Methods:

  • Analysis of 24-h and spot urine samples from three Swedish population studies.

Related Experiment Videos

  • Multiple regression analyses to identify determinants of urinary creatinine and cadmium.
  • ANOVA and ANCOVA to compare gender- and age-related variations in adjusted cadmium levels.

    • Main Results:

    • Body surface area, gender, age, and meat intake were primary determinants of urinary creatinine.
    • Creatinine-adjusted urinary cadmium was significantly higher in women and older individuals.
    • Specific gravity adjustment showed less pronounced gender and age-related differences in cadmium levels.

    Conclusions:

    • Creatinine adjustment for urinary cadmium is more susceptible to variations in age, gender, body size, and meat intake.
    • Specific gravity adjustment appears more robust when comparing individuals or populations with significant differences in muscle mass or diet.
    • Specific gravity adjustment is recommended for biomonitoring studies involving diverse populations or significant variations in influencing factors.