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Gaining weight: the Keystone Symposium on PPAR and LXR
Michael Lehrke1, Gabriel Pascual, Christopher K Glass
1Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Genes & Development
|August 4, 2005
Summary
This review summarizes key findings on Peroxisome Proliferator-Activated Receptors (PPARs) and Liver X Receptors (LXRs), crucial for metabolism. Therapeutic targeting of these lipid-sensing receptors offers potential to combat obesity and diabetes.
Area of Science:
- Molecular Biology
- Metabolic Research
- Endocrinology
Background:
- The nuclear receptor superfamily comprises 48 mammalian transcription factors governing development, inflammation, and metabolism.
- Peroxisome Proliferator-Activated Receptors (PPARs) and Liver X Receptors (LXRs) are key lipid-sensing subclasses involved in metabolic regulation.
Framework:
- This summary highlights discussions from a recent Keystone Symposium focused on PPARs and LXRs.
- The meeting addressed the critical roles of these receptors in lipid and glucose homeostasis.
Implementation:
- Focus on therapeutic strategies for manipulating PPARs and LXRs.
- Exploration of their potential in combating metabolic diseases like obesity and diabetes.
Implications:
- Understanding PPARs and LXRs is vital for developing novel treatments for metabolic disorders.
- Future research directions and therapeutic projections for these metabolic receptors were discussed.