Related Experiment Video
Updated: Aug 16, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Risk factors for late stroke after coronary artery bypass grafting
Thomas Schachner1, Anne Zimmer, Georg Nagele
1Department of Cardiac Surgery, Insbruck Medical University, Austria. Thomas.Schachner@uibk.ac.at
Insights
Postoperative stroke after coronary artery bypass grafting is linked to older age, unstable angina, COPD, carotid artery disease, and aortic atherosclerosis. A history of neurological events is a key predictor of stroke risk.
Area of Science:
- Cardiovascular Surgery
- Neurology
- Vascular Surgery
Background:
- Postoperative stroke is a serious complication following coronary artery bypass grafting (CABG).
- Long-term stroke occurrence significantly impacts patients' quality of life after CABG.
- Identifying risk factors for late stroke is crucial for improving patient outcomes.
Purpose of the Study:
- To determine factors associated with new strokes during long-term follow-up after CABG.
- To identify predictors of late postoperative stroke in patients undergoing CABG.
Main Methods:
- Retrospective analysis of 387 patients undergoing CABG with intraoperative epiaortic ultrasonography.
- Median follow-up of 52 months to assess stroke occurrence.
- Assessment of ascending aortic wall thickness and patient comorbidities.
Main Results:
- Stroke occurred in 7% of patients within the follow-up period.
- Increased stroke risk was associated with age ≥70 years, unstable angina, COPD, carotid artery disease, prior neurologic events, and aortic wall thickness ≥4 mm.
- History of neurologic events was identified as an independent risk factor for stroke.
Conclusions:
- Ascending aortic atherosclerosis, older age, unstable angina, COPD, and carotid artery disease are risk factors for late stroke post-CABG.
- A preoperative history of neurologic events holds significant predictive value for late stroke.
- Risk stratification and targeted interventions can potentially mitigate stroke risk in high-risk CABG patients.
Background:
Postoperative stroke is a severe complication immediately after coronary artery bypass grafting, and it significantly deteriorates the postoperative quality of life if it occurs in the long term. It was the aim of our study to determine factors associated with the occurrence of new strokes during long-term follow-up after coronary artery bypass grafting.
Methods:
From 387 of 500 patients undergoing coronary artery bypass grafting (age, 67 years [33-84 years]; 76% male) who had intraoperative epiaortic ultrasonography for assessment of ascending aortic wall thickness, a complete follow-up regarding postoperative stroke was achieved. The median follow-up time was 52 months (9-74 months).
Results:
A stroke occurred in 26 (7%) of 387 patients, and the cumulative freedom from stroke was 99%, 95%, and 89% after 1, 3, and 5 years, respectively. A significantly lower freedom from stroke was present in patients with an age of 70 years or more (P = .007), preoperative unstable angina (P = .031), chronic obstructive pulmonary disease (P = .009), carotid artery disease (P < .001), preoperative history of neurologic events (P < .001), and a maximum ascending aortic wall thickness of 4 mm or more (P = .010). Multivariate analysis revealed preoperative history of neurologic events (P = .021) to be an independent risk factor.
Conclusion:
Patients with ascending aortic atherosclerosis, older age (> or =70 years), preoperative unstable angina, chronic obstructive pulmonary disease, and carotid artery disease are at risk for late postoperative stroke after coronary artery bypass grafting. A history of neurologic events is of special predictive importance.
Related Concept Videos
Coronary Artery Disease I: Introduction
Peripheral Artery Disease V: Postoperative Nursing Management
Ischemic Stroke l: Introduction
Coronary Artery Disease IV: Preventive Measures
Coronary Artery Disease V: Interprofessional Care
Ischemic Stroke ll: Pathophysiology