[Clinicopathological and histochemical study of adenoma malignum of the uterine cervix]

A clinicopathological and histochemical study has been made on ten cases of adenoma malignum of the cervix. The clinical symptoms and signs of the ten cases were vaginal discharge, vaginal bleeding, and hypertrophy of the cervix. The Papanicolaus classification of the initial smear test obtained by scraping was class III in six cases, class V in two, class IV in one and class II in one. The columnar cells of adenoma malignum showed a weak or negative reaction to high iron diamine (HID) stain and negative to Alcian blue (AB) stain. Normal endocervical columnar cells showed a positive reaction to HID stain and a negative reaction to AB stain. CEA antigen was present in the columnal cells of the adenoma malignum, although normal endocervical glands did not contain CEA.