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Updated: Aug 16, 2026
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
[Animal experimental study of the treatment of periapical disease with recombinant human bone morphogenetic protein-2
Huo-Guang Peng1, Zhu-Ping Wang, Ting-Yan Liu
1Dept. of Dentistry, Affiliated Hospital of the Medical College, Hangzhou Teachers College, Hangzhou 310015, China.
Objective:
To investigate the effect of the treatment of periapical diseases with recombinant human netic protein (rhBMP-2) composite in dog models so as to provide basis for its clinical application.
Methods:
The endotoxin-bacteria mixed fluid was injected into each root canal of the experimental teeth of dogs and the animal periapical were built. The rhBMP-2 composite was mixed by rhBMP-2, TCP, collagen and metronidazole and used in the treatment cal diseases in dog models as root apex screen. The imageology and pathology research were went on.
Results:
The effective rate of the experimental group was remarkably higher than that of the carrier group and the control group with remarkable ference (P < 0.05). The quality of the repair of tissue was obviously better than the two other groups.
Conclusion:
The rhBMP-2 composite is a promising biological root-canal filling material.
