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Updated: Aug 16, 2026

Induction of Cerebral Arterial Gas Embolism in Rat
Published on: October 18, 2024
The potential of venous air embolism ascending retrograde to the brain
Christoph J Schlimp1, Thomas Loimer, Michael Rieger
1Dept. of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Austria. christoph.schlimp@uibk.ac.at
Abstract:
A bench study was performed to investigate the potential of air bubbles entering a central vein via a central venous catheter to ascend retrograde to the brain. The results support the hypothesis that air bubbles may rise retrograde against the venous blood flow, depending on bubble size, central vein diameter and cardiac output. A review of radiological findings in published case reports indicates that the occurrence of retrograde cerebral air embolism is underestimated.
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